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Home / Primary Antibodies / Monoclonal Antibodies

GAPDH mouse mAb(PT0325)

SKU : BHA12104119

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Mfr.No.	BT-MCA0679
Alternative Names	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-)
Categories	Primary Antibodies
Clonality	monoclonal
Description	SETDB1, also named as ESET, KIAA0067 and KMT1E, belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 ‘Lys-9’ trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone ‘Lys-9’ trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation, gene silencing, and transcriptional repression. It has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. .The calculated molecular weight of SETDB1 is 143 kDa, but the modified SETDB1 protein is about 170 kDa.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Host	Mouse(Mu)
Immunogen	Synthesized peptide derived from human GAPDH
Isotype	IgG1
Reactivity	Human
Regulatory	RUO

Weight	143 kDa

Concentration	1 mg/ml
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Store at 4°C for a month, for one year store at -20°C. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-20°C. Avoid repeated freeze/thaw cycles.
Storage Stability	-20°C/1 year

Applications	IHC-P, WB
Description	WB ; ELISA
Dilution	IHC-p 1:100-300，WB 1:500-2000

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SKU	Supplier No.	Size	Your price	Quantity
BHA12104119	BT-MCA0679	100µl	$226		Add to Cart
BHA12104119	BT-MCA0679	50µl	$110.45		Add to Cart
BHA12104119	BT-MCA0679	20µl	$69.16		Add to Cart

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