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Home / Primary Antibodies / IHC Antibodies

GADD45GIP1 Antibody

SKU : BHA10558425

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA039959
Alternative Names	Growth arrest and DNA-damage-inducible proteins-interacting protein 1; CR6-interacting factor 1; CRIF1; CKII beta-associating protein; Papillomavirus L2-interacting nuclear protein 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.Goernemann J., Virology 303:69-78(2002).Chung H.K., J. Biol. Chem. 278:28079-28088(2003).The MGC Project Team, Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human GADD45GIP1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. Goernemann J., Virology 303:69-78(2002). Chung H.K., J. Biol. Chem. 278:28079-28088(2003). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GADD45GIP1 protein.
Subcellular Location	Mitochondrion, Nucleus

Uniprot	Q8TAE8
Database Links	HGNC:29996 OMIM:605162 KEGG:hsa:90480 STRING:9606.ENSP00000323065 UniGene:Hs.515164
Function	Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Protein Families	Mitochondrion-specific ribosomal protein mL64 family
Tissue Specificity	Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary th

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC

Description

ELISA ; IHC, IHC ; ELISA

Dilution

IHC	1:50-1:100

Tested Application

ELISA,IHC;IHC:1:50-1:100

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558425	CSB-PA039959	100ul	$297		Add to Cart

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