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Home / Primary Antibodies

GABRB1 (Ab-434) Antibody

SKU : BHA10557467

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA620050
Alternative Names	GABA(A) receptor; GABA(A)R beta-1; GBRB1; GABA-RB;
Categories	Primary Antibodies
Clonality	polyclonal
Description	The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding a 4, a 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.Collins AL, et al. (2006) Neurogenetics ;7(3):167-174.Ma DQ, et al. (2005) Am J Hum Genet ;77(3):377-388.Edenberg HJ, et al. (2004) Am J Hum Genet ;74(4):705-714.
Host	Rabbit
Immunogen	Peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1.
Involvement In Disease	Epileptic encephalopathy, early infantile, 45 (EIEE45)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding a 4, a 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. Collins AL, et al. (2006) Neurogenetics ;7(3):167-174. Ma DQ, et al. (2005) Am J Hum Genet ;77(3):377-388. Edenberg HJ, et al. (2004) Am J Hum Genet ;74(4):705-714.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total GABRB1 protein.
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein

Uniprot	P18505
Database Links	HGNC:4081 OMIM:137190 KEGG:hsa:2560 STRING:9606.ENSP00000295454 UniGene:Hs.254117
Function	Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
Protein Families	Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557467	CSB-PA620050	100ul	$297		Add to Cart

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