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Home / Antibodies

GAB2 (Ab-623) Antibody

SKU : BHA10557699

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA269356
Alternative Names	GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2; GRB2-associated binder 2; pp100; KIAA0571
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.Nishida K., Blood 93:1809-1816(1999).Nagase T., DNA Res. 5:31-39(1998).Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Gab2 around the phosphorylation site of serine 623 (P-S-S(p)-P-S)., Synthesized non-phosphopeptide derived from Human Gab2 around the phosphorylation site of serine 623 (P-S-S(p)-P-S).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO, RUO
Relevance	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Nishida K., Blood 93:1809-1816(1999). Nagase T., DNA Res. 5:31-39(1998). Salomon A.R., Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Gab2 protein.
Subcellular Location	Cytoplasm, Cell membrane

Uniprot	Q9UQC2
Database Links	HGNC:14458 OMIM:606203 KEGG:hsa:9846 STRING:9606.ENSP00000354952 UniGene:Hs.429434
Function	Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Pathway	Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Osteoclast differentiation Phospholipase D signaling pathway Sphingolipid signaling pathway, Ras signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Osteoclast differentiation Phospholipase D signaling pathway Sphingolipid signaling pathway
Protein Families	GAB family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen., The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

,

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557699	CSB-PA269356	100ul	$297		Add to Cart

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