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Home / Antibodies

FRS2 (Ab-196) Antibody

SKU : BHA10559144

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA208276
Alternative Names	FGFR signalling adaptor; FGFR signalling adaptor SNT-1; SNT-1; SNT2; SUC1-associated neurotrophic factor target
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.The MGC Project Team; Genome Res. 14:2121-2127(2004).Xu H., J. Biol. Chem. 273:17987-17990(1998).Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. The MGC Project Team; Genome Res. 14:2121-2127(2004). Xu H., J. Biol. Chem. 273:17987-17990(1998). Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FRS2 protein.
Subcellular Location	Endomembrane system

Uniprot	Q8WU20
Database Links	HGNC:16971 OMIM:607743 KEGG:hsa:10818 STRING:9606.ENSP00000299293 UniGene:Hs.593446
Function	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Pathway	MAPK Erk pathway Neurotrophin signaling pathway
Tissue Specificity	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559144	CSB-PA208276	100ul	$297		Add to Cart

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