FHX; FOXJ2 forkhead factor; fork head homologous X;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli By similarity. UniProtKB P42128Ota T., Nat. Genet. 36:40-45(2004).Hillier L.W., Nature 424:157-164(2003).Katoh M., Int. J. Mol. Med. 14:127-132(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human FOXK1.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli By similarity. UniProtKB P42128
Ota T., Nat. Genet. 36:40-45(2004). Hillier L.W., Nature 424:157-164(2003). Katoh M., Int. J. Mol. Med. 14:127-132(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total FOXK1 protein.
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor cell population (By similarity). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity). Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus
Tissue Specificity
Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.