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Home / Antibodies

FOS (Ab-232) Antibody

SKU : BHA10557688

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA578446
Alternative Names	activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; Cellular oncogene fos
Categories	Primary Antibodies
Clonality	polyclonal
Description	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.van Straaten F., Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).Hai T., Genes Dev. 3:2083-2090(1989).Heilig R., Nature 421:601-607(2003).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human FOS around the phosphorylation site of threonine 232 (V-A-T(p)-P-E).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. van Straaten F., Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983). Hai T., Genes Dev. 3:2083-2090(1989). Heilig R., Nature 421:601-607(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FOS protein.
Subcellular Location	Nucleus, Endoplasmic reticulum, Cytoplasm, cytosol

Uniprot	P01100
Database Links	HGNC:3796 OMIM:164810 KEGG:hsa:2353 STRING:9606.ENSP00000306245 UniGene:Hs.25647
Function	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Pathway	cAMP signaling pathway Estrogen signaling pathway MAPK signaling pathway TNF signaling pathway Apoptosis B cell receptor signaling pathway IL-17 signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway
Protein Families	BZIP family, Fos subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557688	CSB-PA578446	100ul	$297		Add to Cart

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