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Home / Primary Antibodies

Flt3 ligand Antibody (R32964)

SKU : BHA17106250

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Mfr.No.	R32964
Clonality	Polyclonal
Description	FLT3LG (FMS-Related Tyrosine Kinase 3 Ligand) also called FLT3 ligand, FL or FLT3L, is a protein which in humans is encoded by the FLT3LG gene. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8-positive classical DCs and their CD103-positive tissue counterparts. Flt3 ligand (FL) is a hematopoietic four helical bundlecytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. Lyman et al. (1993) found that Flt3 ligand stimulated proliferation of hematopoietic progenitor cells isolated from mouse fetal liver or adult mouse bone marrow. Hannum et al. (1994) concluded that FL enhances the response of stem and primitive progenitor cells to other growth factors to generate all myeloid lineages except erythroid cells. Assays of C-terminally truncated FL proteins confirmed that the N-terminal half conferred FL activity. Depletion of the Pi3k -Mtor negative regulator Pten facilitated Flt3l-driven DC development in culture.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	A recombinant mouse protein corresponding to amino acids T28-Q189 was used as the immunogen for the Flt3 ligand antibody.
Isotype	IgG
Predicted Reactivity	Mouse
Reactivity	Mouse
Recombinant	No

Uniprot	P49772

Buffer	Lyophilized from 1X PBS with 2.5% BSA, 0.025% sodium azide
Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the Flt3 ligand antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, Direct ELISA
Dilution	Weste Blot: 0.5-1ug/ml,Direct ELISA (recombinant mouse protein): 0.1-0.5ug/ml (BSA-free format available)

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17106250	R32964	100 ug	$419		Add to Cart

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