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Home / Primary Antibodies

FLI1 Antibody (V7218SAF)

SKU : BHA17126151

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NSJ Bioreagents

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Mfr.No.	V7218SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Friend leukemia integration 1 is a member of the ETS family of DNA binding transcription factors that is involved in cellular proliferation and tumorigenesis. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Human partial recombinant protein (amino acids 107-216) was used as the immunogen for this FLI1 antibody.
Isotype	Mouse IgG
Species Reactivity	Human
Note	The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FLI1 antibody to be titered up or down for optimal performance.

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the FLI1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB
Description	Weste blot: 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126151	V7218SAF-100UG	100 ug	$499		Add to Cart

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