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Home / Antibodies

Filaggrin Antibody (V3364SAF)

SKU : BHA17125007

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NSJ Bioreagents

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Mfr.No.	V3364SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal differentiation of epidermal cells. In humans, profilaggrin is encoded by the FLG gene, which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation complex on chromosome 1q21.Filaggrin is essential for the regulation of epidermal homeostasis. Within the stratum coeum, filaggrin monomers can become incorporated into the lipid envelope, which is responsible for the skin barrier function. Alteatively, these proteins can interact with keratin intermediate filaments. Filaggrin undergoes further processing in the upper stratum coeum to release free amino acids that assist in water retention. (Wiki)
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A recombinant human FLG protein was used as the immunogen for this Filaggrin antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Uniprot	P20930

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17125007	V3364SAF-100UG	100 ug	$499		Add to Cart

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