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Home / Primary Antibodies

Fibroblast growth factor receptor 2 Antibody (FGFR2) (F50619)

SKU : BHA17101744

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Mfr.No.	F50619, F50619-0.08ML, F50619-0.4ML
Clonality	Polyclonal
Description	Fibroblast growth factor receptor 2 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patteing, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, intealization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, intealization and degradation lead to aberrant signaling. Over-expressed promotes activation of STAT1. (UniProt)
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 7-37 from the human protein was used as the immunogen for this FGFR2 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P21802

Format	Purified
Purification	Purified
Storage	Aliquot the FGFR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IF, FACS, ELISA
Dilution	Weste blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17101744-1	F50619-0.08ML	0.08ml	$165		Add to Cart
BHA17101744-2	F50619-0.4ML	0.4ml	$379		Add to Cart

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