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Home / Primary Antibodies

FGF23 Antibody

SKU : BHA10559405

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA163892
Alternative Names	Fibroblast growth factor 23; FGF-23; Tumor-derived hypophosphatemia-inducing factor; HYPF;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL By similarity. Acts directly on the parathyroid to decrease PTH secretion By similarity. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.Yamashita T., Biochem. Biophys. Res. Commun. 277:494-498(2000).White K.E., Nat. Genet. 26:345-348(2000).Shimada T., Proc. Natl. Acad. Sci. U.S.A. 98:6500-6505(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human FGF23.
Involvement In Disease	Hypophosphatemic rickets, autosomal dominant (ADHR); Tumoral calcinosis, hyperphosphatemic, familial (HFTC)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL By similarity. Acts directly on the parathyroid to decrease PTH secretion By similarity. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Yamashita T., Biochem. Biophys. Res. Commun. 277:494-498(2000). White K.E., Nat. Genet. 26:345-348(2000). Shimada T., Proc. Natl. Acad. Sci. U.S.A. 98:6500-6505(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FGF23 protein.
Subcellular Location	Secreted

Uniprot	Q9GZV9
Database Links	HGNC:3680 OMIM:193100 KEGG:hsa:8074 STRING:9606.ENSP00000237837 UniGene:Hs.287370
Function	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Pathway	MAPK signaling pathway PI3K-Akt signaling pathway Regulation of actin cytoskeleton Ras signaling pathway Rap1 signaling pathway
Protein Families	Heparin-binding growth factors family
Tissue Specificity	Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559405	CSB-PA163892	100ul	$297		Add to Cart

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