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Home / Primary Antibodies

FGB Antibody

SKU : BHA10558903

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA265678
Alternative Names	FGB; FIBB; Fibrinogen beta chain; fibrinogen; B beta polypeptide
Categories	Primary Antibodies
Clonality	polyclonal
Description	Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.Chung D.W., Biochemistry 22:3244-3250(1983).Chung D.W., Adv. Exp. Med. Biol. 281:39-48(1990).Chung D.W., (In) Liu C.Y., Chien S. (eds.); Fibrinogen, thrombosis, coagulation and fibrinolysis, pp.39-48, Plenum Press, New York (1991).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human FIBB.
Involvement In Disease	Congenital afibrinogenemia (CAFBN); Dysfibrinogenemia, congenital (DYSFIBRIN)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Chung D.W., Biochemistry 22:3244-3250(1983). Chung D.W., Adv. Exp. Med. Biol. 281:39-48(1990). Chung D.W., (In) Liu C.Y., Chien S. (eds.); Fibrinogen, thrombosis, coagulation and fibrinolysis, pp.39-48, Plenum Press, New York (1991).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FIBB protein.
Subcellular Location	Secreted

Uniprot	P02675
Database Links	HGNC:3662 OMIM:134830 KEGG:hsa:2244 STRING:9606.ENSP00000306099 UniGene:Hs.300774
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Pathway	Complement and coagulation cascades
Tissue Specificity	Detected in blood plasma (at protein level).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558903	CSB-PA265678	100ul	$297		Add to Cart

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