Fc receptor-like protein 5; FcR-like protein 5; FcRL5; Fc receptor homolog 5; FcRH5
Categories
Primary Antibodies
Clonality
polyclonal
Description
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.Nakayama Y., Biochem. Biophys. Res. Commun. 285:830-837(2001).Hatzivassiliou G., Immunity 14:277-289(2001).Davis R.S., Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human FCRL5.
Involvement In Disease
A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32).
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Nakayama Y., Biochem. Biophys. Res. Commun. 285:830-837(2001). Hatzivassiliou G., Immunity 14:277-289(2001). Davis R.S., Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total FCRL5 protein.
Subcellular Location
Cell membrane, Single-pass type I membrane protein
May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.
Tissue Specificity
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, iso
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.