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Home / Primary Antibodies

FADD (Ab-191) Antibody

SKU : BHA10557708

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA975869
Alternative Names	FADD; Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain
Categories	Primary Antibodies
Clonality	polyclonal
Description	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis By similarity. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling By similarity.Zhang J., Mol. Cell. Biol. 16:2756-2763(1996).Hsu H., Cell 84:299-308(1996).Carninci P., Science 309:1559-1563(2005)
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human FADD.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis By similarity. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling By similarity. Zhang J., Mol. Cell. Biol. 16:2756-2763(1996). Hsu H., Cell 84:299-308(1996). Carninci P., Science 309:1559-1563(2005)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total FADD protein.

Uniprot	Q61160
Database Links	KEGG:mmu:14082 STRING:10090.ENSMUSP00000033394 UniGene:Mm.5126
Function	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity).
Pathway	TNF signaling pathway Apoptosis Necroptosis IL-17 signaling pathway NOD-like receptor signaling pathway Toll-like receptor signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557708	CSB-PA975869	100ul	$297		Add to Cart

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