Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Host
Rabbit
Immunogen Region
A portion of amino acids 60-94 from human Factor XIIIa was used as the immunogen for the Factor XIIIa antibody.
Isotype
Rabbit Ig
Species Reactivity
Human
Note
The stated application concentrations are suggested starting points. Titration of the Factor XIIIa antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P00488
Format
Antigen affinity purified
Purity
Antigen affinity
Storage
Aliquot the Factor XIIIa antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.