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Home / Primary Antibodies

EZR (Ab-478) Antibody

SKU : BHA10559129

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA679585
Alternative Names	Cytovillin; EZRI; p81; VIL2; Villin 2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.Gould K.L., EMBO J. 8:4133-4142(1989).Turunen O., J. Biol. Chem. 264:16727-16732(1989).Mungall A.J., Nature 425:805-811(2003).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human Ezrin around the phosphorylation site of tyrosine 478 (P-V-Y(p)-E-P).
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Gould K.L., EMBO J. 8:4133-4142(1989). Turunen O., J. Biol. Chem. 264:16727-16732(1989). Mungall A.J., Nature 425:805-811(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Ezrin protein.
Subcellular Location	Apical cell membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, Cell projection, microvillus membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton

Uniprot	P15311
Database Links	HGNC:12691 OMIM:123900 KEGG:hsa:7430 STRING:9606.ENSP00000338934 UniGene:Hs.487027
Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Pathway	Regulation of actin cytoskeleton Leukocyte transendothelial migration
Tissue Specificity	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559129	CSB-PA679585	100ul	$297		Add to Cart

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