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Home / Antibodies

EZH2 Antibody (F53753)

SKU : BHA17119854

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Mfr.No.	F53753-0.4ML
Clonality	Polyclonal (rabbit origin)
Description	EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	This EZH2 antibody was produced from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human EZH2.
Isotype	Rabbit Ig
Species Reactivity	Human, Mouse, Rat
Note	Titration of the EZH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	Q15910

Format	Antigen affinity purified
Purity	Antigen affinity
Storage	Aliquot the EZH2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ELISA
Description	Weste blot: 1:1000,IHC (Paraffin): 1:50-1:100

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119854	F53753-0.4ML	0.4 ml	$379		Add to Cart

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