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Home / Antibodies

EWSR1 Antibody

SKU : BHA10558657

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA216510
Alternative Names	EWS oncogene; Ewing sarcoma breakpoint region 1 protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.Delattre O., Nature 359:162-165(1992).Plougastel B., Genomics 18:609-615(1993).Zucman-Rossi J., Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human EWSR1.
Involvement In Disease	Ewing sarcoma (ES); Angiomatoid fibrous histiocytoma (AFH)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Delattre O., Nature 359:162-165(1992). Plougastel B., Genomics 18:609-615(1993). Zucman-Rossi J., Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total EWSR1 protein.
Subcellular Location	Nucleus, Cytoplasm, Cell membrane

Uniprot	Q01844
Database Links	HGNC:3508 OMIM:133450 KEGG:hsa:2130 STRING:9606.ENSP00000400142 UniGene:Hs.374477
Function	Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Protein Families	RRM TET family
Tissue Specificity	Ubiquitous.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558657	CSB-PA216510	100ul	$297		Add to Cart

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