Rabbit Anti-Human ERK2 (pThr185 + pTyr187) Polyclonal

Mfr.No.	SPC-975, SPC-975D, SPC-975D-A390, SPC-975D-A488, SPC-975D-A594, SPC-975D-BI, SPC-975D-FITC
Immunogen Species	Human
Alternative Names	ERK Antibody, ERT1 Antibody, ERK2 Antibody, Extracellular Signal Regulated Kinase 2 Antibody, MAP kinase 1 Antibody, MAP kinase 2 Antibody, MAP kinase isoform p42 Antibody, MAPK1 Antibody, MAPK2 Antibody, Mitogen-activated protein kinase 1 Antibody, Mitogen-activated protein kinase 2 Antibody, MK01_HUMAN Antibody, P38 Antibody, P40 Antibody, P41 Antibody, P42MAPK Antibody, PRKM1 Antibody, PRKM2 Antibody protein kinase, protein tyrosine kinase ERK2 Antibody
Categories	Antibodies
Cellular Localization	Cytoskeleton, Cytoplasm, Spindle, Nucleus
Certificate Of Analysis	A 1:250 dilution of SPC-975 was sufficient for detection of ERK2 (pThr185 + pTyr187) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human ERK2 (pThr185 + pTyr187) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Thr185 and Tyr187 of human ERK2 (AA 182-188), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Thr185 and Tyr187 of human ERK2 (AA 182-188)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	P28482
Accession Number	NP_002736.3
Gene Id	5594
Target	ERK2 (pThr185 + pTyr187)
Research Area	Neurodegeneration, Alzheimer's Disease, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Stem Cells, Signaling Pathways, Cytoplasmic, Immunology, Innate Immunity, Cytokines, Interleukins, Extracellular Matrix (ECM), Focal Adhesions, Cancer, Oxidative Stress, Golgi Proteins, Neuroscience, Protein Trafficking, TGF Beta

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	ERK2 or MAPK1 is a protein-serine/threonine kinase. Phosphorylates many diffrent transcription factors, such as ELK1. Acts as transcriptional repressor by binding directly to DNA. Essential for cyclin D1 induction. MAPK1 phosphoryltaes BCL2, which contributes to cell survival, the suppression of the apoptotic effect of BAD and up-regulation of the antiapoptotic protein MCL-1. Regulates accumulation of p53 during DNA damage response. Constitutively active in many human tumours, supposedly due to altered RAS, RAF, EGFR or other upstream elements. ERK/MAPK pathway was shown to promote cell motilty and tumour cell migration.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 41.39 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912366-1	SPC-975D	Unconjugated	100 ul	$331	Add to Cart
BHA11912366-2	SPC-975D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912366-3	SPC-975D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912366-4	SPC-975D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912366-5	SPC-975D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912366-6	SPC-975D-FITC	FITC	100 ul	$375	Add to Cart

ERK2 Antibody (pThr185 + pTyr187) - SPC-975

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