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Home / Primary Antibodies / Polyclonal Antibodies

ERK1 Antibody (pTyr204) - SPC-974

BHA11912348
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot P27361
Accession Number NP_001035145
Gene Id 5595
Target ERK1 (pTyr204)
Research Area Neurodegeneration, Alzheimer's Disease, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Stem Cells, Signaling Pathways, Cytoplasmic, Immunology, Innate Immunity, Cytokines, Interleukins, Extracellular Matrix (ECM), Focal Adhesions, Cancer, Oxidative Stress, Neuroscience, TGF Beta
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background ERK1 or MAPK3 is ubiquitously expressed protein serine/threonine kinase involved in regulating cellular differentiation and proliferation in response to extracellular mitogens or growth factors. MAPK3 is activated by upstream signalling by monomeric G-proteins. MAPK3 activation leads to its translocation from the cytosol to the nucleus where it can target substrate proteins involved in cell cycle regulation; Cyclin D1, suppression of apoptosis; BCL2 and BAD, tumour supression; p53, cell migration; PAI-1, and MHCII mediated immune response; PPARg1. Dysfunction of MAPK3 expression and activity has been observed in a variety of cancers. Predominantly overexpression of MAPK3 or constitutive activation has been observed in cancer cell lines. Activation of MAPK3 does not appear to be due to mutations in the protein itself but rather aberrant signalling in upstream factors including Raf, Ras and epidermal growth factor receptor. MAPK3 may also have a role in promoting metastasis in invasive tumours.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 43.136 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11912348-1 SPC-974D Unconjugated 100 ul $331
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BHA11912348-2 SPC-974D-A390 ATTO 390 100 ul $385
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BHA11912348-3 SPC-974D-A488 ATTO 488 100 ul $384
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BHA11912348-4 SPC-974D-A594 ATTO 594 100 ul $384
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BHA11912348-5 SPC-974D-BI Biotin 100 ul $380
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BHA11912348-6 SPC-974D-FITC FITC 100 ul $375
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