Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
Formulation
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host
Mouse
Immunogen Region
A synthetic peptide corresponding to a portion of human ERK1 was used as the immunogen for this ERK1/2 antibody.
Isotype
Mouse lgG1
Species Reactivity
Human, Mouse, Rat
Note
The stated application concentrations are suggested starting points. Titration of the ERK1/2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.