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Home / Antibodies

ERCC5 Antibody

SKU : BHA10557837

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA160852
Alternative Names	DNA excision repair protein ERCC-5; DNA-repair protein complementing XP-G cells; ERCC5; XPGC; Xeroderma pigmentosum group G complementing protein
Categories	Primary Antibodies
Clonality	polyclonal
Description	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.Scherly D., Nature 363:182-185(1993).Shiomi T., Mutat. Res. 314:167-175(1994).Macinnes M.A., Mol. Cell. Biol. 13:6393-6402(1993).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ERCC5.
Involvement In Disease	Xeroderma pigmentosum complementation group G (XP-G); Cerebro-oculo-facio-skeletal syndrome 3 (COFS3)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too. Scherly D., Nature 363:182-185(1993). Shiomi T., Mutat. Res. 314:167-175(1994). Macinnes M.A., Mol. Cell. Biol. 13:6393-6402(1993).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ERCC5 protein.
Subcellular Location	Nucleus

Uniprot	P28715
Database Links	HGNC:3437 OMIM:133530 KEGG:hsa:2073 STRING:9606.ENSP00000347978 UniGene:Hs.258429
Function	Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
Pathway	DNA repair pathway
Protein Families	XPG/RAD2 endonuclease family, XPG subfamily

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557837	CSB-PA160852	100ul	$297		Add to Cart

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