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Home / Antibodies

EPHA3 (Ab-602) Antibody

SKU : BHA10557717

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA030077
Alternative Names	EK4; EPH receptor A3; EPH-like kinase 4; eph-like tyrosine kinase 1; EPHA3
Antigen	EphA3
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.Wicks I.P., Proc. Natl. Acad. Sci. U.S.A. 89:1611-1615(1992).Chiari R., Cancer Res. 60:4855-4863(2000).Boyd A.W., J. Biol. Chem. 267:3262-3267(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human EPHA3.
Involvement In Disease	Colorectal cancer (CRC)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. Wicks I.P., Proc. Natl. Acad. Sci. U.S.A. 89:1611-1615(1992). Chiari R., Cancer Res. 60:4855-4863(2000). Boyd A.W., J. Biol. Chem. 267:3262-3267(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total EPHA3 protein.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Secreted

Uniprot	P29320
Database Links	HGNC:3387 OMIM:114500 KEGG:hsa:2042 STRING:9606.ENSP00000337451 UniGene:Hs.123642
Function	Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Protein Families	Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Tissue Specificity	Widely expressed. Highest level in placenta.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557717	CSB-PA030077	100ul	$297		Add to Cart

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