JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / IHC Antibodies

EP300/CREBBP Antibody

SKU : BHA10559203

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

CUSABIO TECHONOLOGY LLC

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	CSB-PA265859
Alternative Names	CREB-binding protein; CREBBP E1A-associated protein p300; EP300; P300 transcription coactivator homolog;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.Gerd A. Blobel, J. Leukoc. Biol., Apr 2002; 71: 545. Eric Kalkhoven, Hum. Mol. Genet., Feb 2003; 12: 441 - 450. Wei-fang Shen, Mol. Cell. Biol., Nov 2001; 21: 7509 - 7522. Frederick C. Nucifora, Science, Mar 2001; 291: 2423.
Host	Rabbit
Immunogen	Synthesized peptide derived from Human P300/CBP.
Involvement In Disease	Rubinstein-Taybi syndrome 2 (RSTS2)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Gerd A. Blobel, J. Leukoc. Biol., Apr 2002; 71: 545. Eric Kalkhoven, Hum. Mol. Genet., Feb 2003; 12: 441 - 450. Wei-fang Shen, Mol. Cell. Biol., Nov 2001; 21: 7509 - 7522. Frederick C. Nucifora, Science, Mar 2001; 291: 2423.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total P300/CBP protein.
Subcellular Location	Cytoplasm, Nucleus, Chromosome

Uniprot	Q09472
Database Links	HGNC:3373 OMIM:602700 KEGG:hsa:2033 STRING:9606.ENSP00000263253 UniGene:Hs.517517
Function	Functions as histone acetyltransferase and regulates transcription via chromatin remodeling
Pathway	cAMP signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway Melanogenesis Notch signaling pathway TGF-beta signaling pathway Wnt signaling pathway Cell cycle FoxO signaling pathway Glucagon signaling pathway

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC, WB ; ELISA ; IHC

Dilution

WB	1:500-1:3000
IHC	1:50-1:100

Tested Application

ELISA,WB,IHC;WB:1:500-1:3000,IHC:1:50-1:100

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHA10559203	CSB-PA265859	100ul	$297		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.