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Home / Primary Antibodies / Polyclonal Antibodies

ENaC alpha Antibody - SPC-403

BHA11907805
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+1 866.986.9598
Email
[email protected]
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Swissprot Q6IRJ1
Accession Number NP_113736
Gene Id 25122
Target ENaC
Research Area Neurotransmission, Ion Channels, Sodium Channels, Epithelial Sodium Channels (ENaC), Neuroscience
Buffer PBS, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:400); optimal dilutions for assays should be determined by the user.
Purification Protein A Purified
Scientific Background The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2).
ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~85kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF, IP
Description WB ; IHC ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:400); IHC (1:25); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689.

2. Gu Y. (2008) J Cell Physiol. 216(2):453-457.

3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609.

4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594.

5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45.

6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907805-1 SPC-403D Unconjugated 100 ug $341
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BHA11907805-2 SPC-403D-A390 ATTO 390 100 ug $395
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BHA11907805-3 SPC-403D-A488 ATTO 488 100 ug $394
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BHA11907805-4 SPC-403D-A594 ATTO 594 100 ug $394
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BHA11907805-5 SPC-403D-ALP Alkaline Phosphatase 100 ug $387
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BHA11907805-6 SPC-403D-APC APC 100 ug $393
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BHA11907805-7 SPC-403D-BI Biotin 100 ug $389
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BHA11907805-8 SPC-403D-FITC FITC 100 ug $385
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BHA11907805-9 SPC-403D-HRP HRP 100 ug $381
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BHA11907805-10 SPC-403D-PCP PerCP 100 ug $393
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BHA11907805-11 SPC-403D-RPE RPE 100 ug $391
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BHA11907805-12 SPC-403S Unconjugated 12 ug $44
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