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Home / Primary Antibodies

ELL Antibody

SKU : BHA10557884

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA795035
Alternative Names	RNA polymerase II elongation factor ELL; RNA polymerase II elongation factor ELL; ELL; C19orf17;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.Thirman M.J., Proc. Natl. Acad. Sci. U.S.A. 91:12110-12114(1994).Simone F., Blood 98:201-209(2001).Kong S.E., Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ELL.
Involvement In Disease	A chromosomal aberration involving ELL is found in acute leukemias. Translocation t(11;19)(q23;p13.1) with KMT2A/MLL1. The result is a rogue activator protein.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation. Thirman M.J., Proc. Natl. Acad. Sci. U.S.A. 91:12110-12114(1994). Simone F., Blood 98:201-209(2001). Kong S.E., Proc. Natl. Acad. Sci. U.S.A. 102:10094-10098(2005).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ELL protein.
Subcellular Location	Nucleus, Nucleus speckle, Nucleus, Cajal body

Uniprot	P55199
Database Links	HGNC:23114 OMIM:600284 KEGG:hsa:8178 STRING:9606.ENSP00000262809 UniGene:Hs.515260
Function	Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III
Protein Families	ELL/occludin family
Tissue Specificity	Expressed in all tissues tested. Highest levels found in placenta, skeletal muscle, testis and peripheral blood leukocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557884	CSB-PA795035	100ul	$297		Add to Cart

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