eIF4A1 is a 406 amino acid ATP-dependent RNA helicase belonging to the DEAD box helicase family and eukaryotic initiation factor-4A subfamily with a helicase ATP-binding domain and a helicase C-terminal domain. eIF4F eukaryotic translation initiation complex is formed by the association of eIF4A1 with eIF4E and eIF4E kinase (MNK1), eIF4B, eIF4G, PABPC1. It is closely related to eIF4A2. eIF4A1 is a eukaryotic translation initiation factor involved in protein translation/synthesis where it helps in unwinding the secondary structure of RNA in the 5'-UTR of mRNAs, cap recognition, and is necessary for efficient binding mRNA to the 40S small ribosomal subunit, as well as subsequent scanning for the initiator codon. Ubiquitous expression of the enzyme eIF4A1 is seen in most tissues
Clonality
Monoclonal
Formulation
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Host
Mouse
Immunogen
Synthetic Peptide
Isotype
Mouse IgG1
Reactivity
Human, Mouse, Rat
Gene Id
1973
Concentration
1 mg/ml
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
Storage Buffer
PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol