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Home / Antibodies

EIF2AK3 Antibody

SKU : BHA10559362

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA590642
Alternative Names	E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK
Categories	Primary Antibodies
Clonality	polyclonal
Description	Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity.Sood R., Biochem. J. 346:281-293(2000).Delepine M., Nat. Genet. 25:406-409(2000).Shi Y., J. Biol. Chem. 274:5723-5730(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human E2AK3.
Involvement In Disease	Wolcott-Rallison syndrome (WRS)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity. Sood R., Biochem. J. 346:281-293(2000). Delepine M., Nat. Genet. 25:406-409(2000). Shi Y., J. Biol. Chem. 274:5723-5730(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total E2AK3 protein.
Subcellular Location	Endoplasmic reticulum membrane, Single-pass type I membrane protein

Uniprot	Q9NZJ5
Database Links	HGNC:3255 OMIM:226980 KEGG:hsa:9451 STRING:9606.ENSP00000307235 UniGene:Hs.591589
Function	Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Pathway	Apoptosis Autophagy Protein processing in endoplasmic reticulum
Protein Families	Protein kinase superfamily, Ser/Thr protein kinase family, GCN2 subfamily
Tissue Specificity	Ubiquitous. A high level expression is seen in secretory tissues.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559362	CSB-PA590642	100ul	$297		Add to Cart

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