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Home / Antibodies

EGR2 Antibody

SKU : BHA10557801

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA891042
Alternative Names	AT591; CMT1D; CMT4E; DKFZp686J1957; early growth response 2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.Joseph L.J., Proc. Natl. Acad. Sci. U.S.A. 85:7164-7168(1988).Warner L.E., Nat. Genet. 18:382-384(1998).Bechtel S., BMC Genomics 8:399-399(2007).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human EGR2.
Involvement In Disease	Neuropathy, congenital hypomyelinating or amyelinating (CHN); Charcot-Marie-Tooth disease 1D (CMT1D); Dejerine-Sottas syndrome (DSS)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Joseph L.J., Proc. Natl. Acad. Sci. U.S.A. 85:7164-7168(1988). Warner L.E., Nat. Genet. 18:382-384(1998). Bechtel S., BMC Genomics 8:399-399(2007).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total EGR2 protein.
Subcellular Location	Nucleus

Uniprot	P11161
Database Links	HGNC:3239 OMIM:129010 KEGG:hsa:1959 STRING:9606.ENSP00000242480 UniGene:Hs.1395
Function	Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.
Protein Families	EGR C2H2-type zinc-finger protein family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557801	CSB-PA891042	100ul	$297		Add to Cart

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