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Home / Antibodies

EFEMP1 Antibody

SKU : BHA10558396

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA274200
Alternative Names	EGF-containing fibulin-like extracellular matrix protein 1; Fibulin-3; FIBL-3; Fibrillin-like protein; Extracellular protein S1-5
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.Lecka-Czernik B., Mol. Cell. Biol. 15:120-128(1995).Ikegawa S., Genomics 35:590-592(1996).Giltay R., Matrix Biol. 18:469-480(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human EFEMP1.
Involvement In Disease	Doyne honeycomb retinal dystrophy (DHRD)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Lecka-Czernik B., Mol. Cell. Biol. 15:120-128(1995). Ikegawa S., Genomics 35:590-592(1996). Giltay R., Matrix Biol. 18:469-480(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total EFEMP1 protein.
Subcellular Location	Secreted, extracellular space, Secreted, extracellular space, extracellular matrix

Uniprot	Q12805
Database Links	HGNC:3218 OMIM:126600 KEGG:hsa:2202 STRING:9606.ENSP00000347596 UniGene:Hs.732348
Function	Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
Protein Families	Fibulin family
Tissue Specificity	In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558396	CSB-PA274200	100ul	$297		Add to Cart

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