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Home / Antibodies

E2F6 Antibody (R30909)

SKU : BHA17104448

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NSJ Bioreagents

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Mfr.No.	R30909
Clonality	Polyclonal
Description	E2F transcription factor 6 is also known as E2F-6. Northe blot analysis revealed that E2F6 is expressed as two mRNAs, 2.5 and 3.5 kb, in all human tissues and cell lines tested. The predicted human and mouse protein sequences are 92% identical. The DNA-binding and dimerization domains of E2F6 are highly related to those of other E2F family members, but this protein lacks the sequences necessary for either transcriptional activation or binding to RB1, p107, or p130. E2F6 can act to repress the transcription of E2F-responsive genes by countering the activity of other E2F complexes. It contributes to gene silencing in a manner independent of retinoblastoma protein family members. It is found in a multimeric protein complex that contains MGA and MAX, and thus the complex can bind not only to the E2F binding site but also to MYC- and Brachyury- binding sites.The E2F6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the middle region of human E2F6 (KDCAQQLFELTDDKEN) was used as the immunogen for this E2F6 antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Uniprot	O75461

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the E2F6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104448	R30909	100 ug	$419		Add to Cart

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