Dopamine receptor D1 is the most highly expressed DA receptor subtype among the DA receptor family. Receptors for dopamine have been classified into two functional types, D1 and D2. They belong to the family of receptors acting through G (or guanine nucleotide-binding) proteins. D2Rs inhibit adenylyl cyclase, but D1Rs stimulate adenylyl cyclase and activate cyclic AMP-dependent protein kinases. DRD1/2 are targets of drug therapy in many psychomotor disorders, including Parkinson's disease and schizophrenia, and may also have a role in drug addiction and alcoholism. D1Rs regulate neuron growth and differentiation, influence behaviour and modify DRD2-mediated events. And the presence of a DRD1 gene restriction fragment length polymorphism will be helpful for future disease linkage studies. This protein also regulates the neurochemical architecture of the striatum and is critical for the normal expression of motor activity.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 221-242 (AQKQIRRIAALERAAVHAKNCQ-human) were used as the immunogen for this DRD1 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
P21728
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
The DRD1 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaws.
Applications
WB, IHC-P
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml