Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases By similarity. HAMAP-Rule MF_03036Lewis B.C., Mol. Cell. Biol. 17:4967-4978(1997).Shin S., J. Cell. Biochem. 105:866-874(2008).Mungall A.J., Nature 425:805-811(2003)
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human RCL.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases By similarity. HAMAP-Rule MF_03036
Lewis B.C., Mol. Cell. Biol. 17:4967-4978(1997). Shin S., J. Cell. Biochem. 105:866-874(2008). Mungall A.J., Nature 425:805-811(2003)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total RCL protein.
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
Protein Families
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
Tissue Specificity
Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.