Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis." Soulet F., Yarar D., Leonard M., Schmid S.L. Mol. Biol. Cell 16:2058-2067(2005)
Host
Rabbit
Immunogen
Peptide sequence around aa.774~778(S-P-T-S-S) derived from Human Dynamin 1, Peptide sequence around aa.774~778(S-P-T-S-S) derived from Human Dynamin 1
Involvement In Disease
Epileptic encephalopathy, early infantile, 31 (EIEE31)
Raised In
Rabbit, Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis." Soulet F., Yarar D., Leonard M., Schmid S.L. Mol. Biol. Cell 16:2058-2067(2005)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Dynamin 1 protein.
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
Pathway
Oxidative Phosphorylation Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle, Oxidative Phosphorylation Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle
Protein Families
TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family
Buffer
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide., Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.