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Home / Primary Antibodies

DNAL1 Antibody

SKU : BHA10558392

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA568072
Alternative Names	C14orf168; dynein light chain 1; axonemal;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.Horvath J., Am. J. Respir. Cell Mol. Biol. 33:41-47(2005).The German cDNA consortium; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.The MGC Project Team; Genome Res. 14:2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human DNAL1.
Involvement In Disease	Ciliary dyskinesia, primary, 16 (CILD16)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants. Horvath J., Am. J. Respir. Cell Mol. Biol. 33:41-47(2005). The German cDNA consortium; Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases. The MGC Project Team; Genome Res. 14:2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DNAL1 protein.
Subcellular Location	Cytoplasm, cytoskeleton, cilium axoneme

Uniprot	Q4LDG9
Database Links	HGNC:23247 OMIM:610062 KEGG:hsa:83544 STRING:9606.ENSP00000452037 UniGene:Hs.271270
Function	Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-right asymmetry
Protein Families	Dynein light chain LC1-type family
Tissue Specificity	Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558392	CSB-PA568072	100ul	$297		Add to Cart

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