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Home / Primary Antibodies

DMC1 Antibody (V7680SAF)

SKU : BHA17126871

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NSJ Bioreagents

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Mfr.No.	V7680SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA repair proteins Rad51 and Rad52 are key components of the doublestrand-break repair (DSBR) pathway. Rad51 is essential for mitotic and meiotic recombination, and its mutation in yeast and mammalian cells results in chromosome loss. Overexpression of Rad52 confers resistance to ionizing radiation and induces homologous intrachromosomal recombination. Rad52 is thought to be involved in an early stage of Rad51-mediated recombination. Additional proteins involved in the pathway include Nibrin and Dmc1 (Meiotic recombination protein DMC1/LIM15 homolog). Nibrin, which complexes with Mre11 and Rad50, is absent in Nijemegen breakage syndrome (NBS) patients. Dmc1 is specifically involved in meiotic recombination. An alteative spliced form of Dmc1, designated Dmc1-D, is deleted for a region between the two motifs involved in nucleotide binding. The alteatively spliced Dmc1-D transcript is detected in both male and female germ cells, indicating that the encoded protein may have a role in mammalian genetic recombination in meiosis.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A recombinant full-length human protein was used as the immunogen for the DMC1 antibody.
Isotype	Mouse IgG2a, kappa
Species Reactivity	Human, Mouse, Rat
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	Q14565

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the DMC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IF, WB, IHC-P
Description	Immunofluorescence: 1-2ug/ml,Weste blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/dmc1-antibody-2h12-4-v7680" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126871	V7680SAF-100UG	100 ug	$499		Add to Cart

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