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Home / Antibodies

DKC1 Antibody

SKU : BHA10559248

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA820074
Alternative Names	CBF5 homolog; DKC1; EC 5.4.99.-; Nucleolar protein NAP57;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Isoform 1:Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.Isoform 3:Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).Heiss N.S., Nat. Genet. 19:32-38(1998).Knight S.W., Am. J. Hum. Genet. 65:50-58(1999).Hassock S., Genomics 55:21-27(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human Dyskerin.
Involvement In Disease	Dyskeratosis congenita, X-linked (DKCX); Hoyeraal-Hreidarsson syndrome (HHS)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Isoform 1:Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.Isoform 3:Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells). Heiss N.S., Nat. Genet. 19:32-38(1998). Knight S.W., Am. J. Hum. Genet. 65:50-58(1999). Hassock S., Genomics 55:21-27(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Dyskerin protein.
Subcellular Location	Isoform 1: Nucleus, nucleolus, Nucleus, Cajal body

Uniprot	O60832
Database Links	HGNC:2890 OMIM:300126 KEGG:hsa:1736 STRING:9606.ENSP00000358563 UniGene:Hs.4747
Function	Isoform 1
Protein Families	Pseudouridine synthase TruB family
Tissue Specificity	Ubiquitously expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559248	CSB-PA820074	100ul	$297		Add to Cart

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