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Home / Primary Antibodies

Di-methyl-H3F3A (K79) Antibody

SKU : BHA10534030

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA010109OA79me2HU
Alternative Names	Histone H3.3, H3F3A; H3F3B, H3.3A H3F3; H3.3B
Categories	Primary Antibodies
Clonality	polyclonal
Description	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Host	Rabbit
Immunogen	Peptide sequence around site of Di-methyl-Lys(79) derived from Human Histone H3.3
Involvement In Disease	Glioma (GLM)
Isotype	IgG
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Species	Homo Sapiens (Human)
Subcellular Location	Nucleus, Chromosome

Uniprot	P84243
Database Links	HGNC:4764 OMIM:137800 KEGG:hsa:3020 STRING:9606.ENSP00000355778 UniGene:Hs.180877
Function	Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Protein Families	Histone H3 family
Research Area	Epigenetics and Nuclear Signaling

Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Format	Liquid
Purification	Antigen Affinity Purified
Purity	Antigen Affinity Purified
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA ; ChIP

Dilution

WB	1:500-1:5000

Tested Application

ELISA, WB, ChIP; Recommended dilution: WB:1:500-1:2000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Native Chromatin Immunoprecipitation(ChIP) Protocol

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10534030	CSB-PA010109OA79me2HU	100ul	$319		Add to Cart
BHA10534030	CSB-PA010109OA79me2HU	50ul	$175		Add to Cart

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