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Home / Antibodies

DHRS2 Antibody

SKU : BHA10558377

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA273664
Alternative Names	dehydrogenase/reductase (SDR family) member 2; dehydrogenase/reductase SDR family member 2; HEP27; protein D; SDR25C1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.Gabrielli F., Eur. J. Biochem. 232:473-477(1995).Pellegrini S., Biochim. Biophys. Acta 1574:215-222(2002).Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human DHRS2.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. Gabrielli F., Eur. J. Biochem. 232:473-477(1995). Pellegrini S., Biochim. Biophys. Acta 1574:215-222(2002). Suzuki Y., Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DHRS2 protein.
Subcellular Location	Mitochondrion matrix, Nucleus

Uniprot	Q13268
Database Links	HGNC:18349 OMIM:615194 KEGG:hsa:10202 STRING:9606.ENSP00000344674 UniGene:Hs.272499
Function	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Protein Families	Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity	Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558377	CSB-PA273664	100ul	$297		Add to Cart

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