Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alteative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. (provided by RefSeq).
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 290-320 from the human protein was used as the immunogen for this DDR2 antibody.
Isotype
IgG1
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Uniprot
Q16832
Clone No
484CT5.5.4
Format
Ascites
Purification
Ascites
Storage
Aliquot the DDR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.