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Home / Antibodies

DDR1 Antibody (R30978)

SKU : BHA17104504

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NSJ Bioreagents

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Mfr.No.	R30978
Clonality	Polyclonal
Description	Discoidin domain receptor family, member 1, also known as NEP, EDDR1, NTRK4, TRKE, DDR, CAK or RTK6, is a human gene. The protein encoded by this gene is a DDR that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. The fibrillar collagens and immobilized collagen activated DDR1 receptor phosphorylation after prolonged treatment. Bhatt et al.(2000) showed that the protein was highly expressed in the cerebellum of developing and adult mouse brain, and that both DDR1 and Collagen IV were highly expressed in the pial layer of the cerebellar cortex. Cocultures of Collagen I- and IV-expressing mouse pial cells with DDR1-expressing granule cells resulted in granule cell neurite extension. Inhibition of collagen-DDR1 signaling reduced granule cell neurite elongation.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human DDR1/RKT6 (FSQLHRFLAEDALNTV) was used as the immunogen for this DDR1 antibody.
Isotype	IgG
Predicted Reactivity	Human, Rat
Reactivity	Human, Rat
Recombinant	No

Uniprot	Q08345

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the DDR1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Weste blot: 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104504	R30978	100 ug	$419		Add to Cart

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