Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.Scott S. Grieshaber, J. Cell Sci., Sep 2003; 116: 3793. Janis K. Burkhardt, J. Cell Biol., Oct 1997; 139: 469. Karin A. Melkonian, J. Biol. Chem., Apr 2007; 10.1074.Lili Yue, J. Biol. Chem., Jul 2000; 275: 23948.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human MMP-23 antibody.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Scott S. Grieshaber, J. Cell Sci., Sep 2003; 116: 3793. Janis K. Burkhardt, J. Cell Biol., Oct 1997; 139: 469. Karin A. Melkonian, J. Biol. Chem., Apr 2007; 10.1074. Lili Yue, J. Biol. Chem., Jul 2000; 275: 23948.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total MMP-23 protein.
Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Membrane, Peripheral membrane protein
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Protein Families
Dynactin subunit 2 family
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.