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Home / Primary Antibodies

DCC Antibody

SKU : BHA10558134

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA081145
Alternative Names	colorectal cancer suppressor; deleted in colorectal carcinoma; netrin receptor DCC; tumor suppressor protein DCC;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.Hedrick L., Genes Dev. 8:1174-1183(1994).Cho K.R., Genomics 19:525-531(1994).Sjoeblom T., Science 314:268-274(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human DCC.
Involvement In Disease	Mirror movements 1 (MRMV1); Gaze palsy, familial horizontal, with progressive scoliosis, 2 (HGPPS2)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Hedrick L., Genes Dev. 8:1174-1183(1994). Cho K.R., Genomics 19:525-531(1994). Sjoeblom T., Science 314:268-274(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DCC protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	P43146
Database Links	HGNC:2701 OMIM:120470 KEGG:hsa:1630 STRING:9606.ENSP00000389140 UniGene:Hs.162025
Function	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Protein Families	Immunoglobulin superfamily, DCC family
Tissue Specificity	Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:500

Tested Application

ELISA,IF;IF:1:100-1:500

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558134	CSB-PA081145	100ul	$297		Add to Cart

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