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Home / Antibodies

DBF4 Antibody

SKU : BHA10558047

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA113425
Alternative Names	Protein DBF4 homolog A; Activator of S phase kinase; DBF4-type zinc finger-containing protein 1; Chiffon homolog A; DBF4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.Kumagai H., Mol. Cell. Biol. 19:5083-5095(1999).Jiang W., EMBO J. 18:5703-5713(1999).Ota T., Nat. Genet. 36:40-45(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human DBF4.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Kumagai H., Mol. Cell. Biol. 19:5083-5095(1999). Jiang W., EMBO J. 18:5703-5713(1999). Ota T., Nat. Genet. 36:40-45(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total DBF4 protein.
Subcellular Location	Nucleus

Uniprot	Q9UBU7
Database Links	HGNC:17364 OMIM:604281 KEGG:hsa:10926 STRING:9606.ENSP00000265728 UniGene:Hs.485380
Function	Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle.
Pathway	Cell cycle
Tissue Specificity	Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558047	CSB-PA113425	100ul	$297		Add to Cart

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