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Home / Antibodies

Cytochrome P450 2C19 Antibody

SKU : BHA12903165

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AFFINITY BIOSCIENCES LTD

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Mfr.No.	AF0744
Alternative Names	(R)-limonene 6-monooxygenase ; (S)-limonene 6-monooxygenase ; (S)-limonene 7-monooxygenase ; CYP2C19 ; CYPIIC17 ; CYPIIC19 ; Cytochrome P450 2C19 ; Cytochrome P450-11A ; Cytochrome P450-254C ; Mephenytoin 4-hydroxylase ;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24
Immunogen	A synthesized peptide derived from human Cytochrome P450 2C19.
Molecular Weight	Observed Mol.Wt.: 56kDa. Predicted Mol.Wt.: 56kDa.
Reactivity	Human
Specificity	Cytochrome P450 2C19 Antibody detects endogenous levels of Cytochrome P450 2C19.
Subcellular Location	Endoplasmic reticulum membrane. Microsome membrane.

Uniprot

P33261

Gene Id

1557

Sequence

10	20	30	40	50
MDPFVVLVLC	LSCLLLLSIW	RQSSGRGKLP	PGPTPLPVIG	NILQIDIKDV
60	70	80	90	100
SKSLTNLSKI	YGPVFTLYFG	LERMVVLHGY	EVVKEALIDL	GEEFSGRGHF
110	120	130	140	150
PLAERANRGF	GIVFSNGKRW	KEIRRFSLMT	LRNFGMGKRS	IEDRVQEEAR
160	170	180	190	200
CLVEELRKTK	ASPCDPTFIL	GCAPCNVICS	IIFQKRFDYK	DQQFLNLMEK
210	220	230	240	250
LNENIRIVST	PWIQICNNFP	TIIDYFPGTH	NKLLKNLAFM	ESDILEKVKE
260	270	280	290	300
HQESMDINNP	RDFIDCFLIK	MEKEKQNQQS	EFTIENLVIT	AADLLGAGTE
310	320	330	340	350
TTSTTLRYAL	LLLLKHPEVT	AKVQEEIERV	VGRNRSPCMQ	DRGHMPYTDA
360	370	380	390	400
VVHEVQRYID	LIPTSLPHAV	TCDVKFRNYL	IPKGTTILTS	LTSVLHDNKE
410	420	430	440	450
FPNPEMFDPR	HFLDEGGNFK	KSNYFMPFSA	GKRICVGEGL	ARMELFLFLT
460	470	480	490
FILQNFNLKS	LIDPKDLDTT	PVVNGFASVP	PFYQLCFIPV

Concentration	1mg/ml
Format	Liquid
Purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Applications	IF/ICC, ELISA, WB
Dilution	WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Manual
MSDS
IF/ICC Protocol.
Western Blotting Handbook.

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SKU	Supplier No.	Size	Your price	Quantity
BHA12903165	AF0744	100ul	$280		Add to Cart
BHA12903165	AF0744	200ul	$350		Add to Cart

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