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Home / Primary Antibodies

Cyclin D2 Antibody (CCND2) (F52196)

SKU : BHA17102037

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NSJ Bioreagents

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Mfr.No.	F52196, F52196-0.08ML, F52196-0.4ML
Clonality	Polyclonal
Description	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the teary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 258-285 from the human protein was used as the immunogen for this Cyclin D2 antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P30279

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the Cyclin D2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Dilution	Weste blot: 1:1000

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17102037-1	F52196-0.08ML	0.08ml	$165		Add to Cart
BHA17102037-2	F52196-0.4ML	0.4ml	$379		Add to Cart

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