Cyclin B1 is a protein that in humans is encoded by the CCNB1 gene, and it is mapped to 5q13.2. It is a regulatory protein involved in mitosis. The gene product complexes with<a href=../search_result.php?search_txt=cdc2>p34(Cdc2)</a>to form the maturation-promoting factor (MPF). Two alteative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alteate transcription initiation sites. CCNB1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and positive feedback loops ensure that once the<a href=../search_result.php?search_txt=cyclin b1>Cyclin B1</a>-<a href=../search_result.php?search_txt=cdk1>Cdk1</a>complex is activated, it is not deactivated.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Human partial recombinant protein (AA 1-433) was used as the immunogen for this Cyclin B1 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Gene Id
891
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the Cyclin B1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.