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Home / Antibodies

CXADR Antibody

SKU : BHA10558364

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA830526
Alternative Names	CAR; Coxsackievirus and adenovirus receptor precursor; Coxsackievirus B- adenovirus receptor; CVB3 binding protein; CXAR
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997).Bergelson J.M., Science 275:1320-1323(1997).Bowles K.R., Hum. Genet. 105:354-359(1999).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human CXADR.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. Tomko R.P., Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997). Bergelson J.M., Science 275:1320-1323(1997). Bowles K.R., Hum. Genet. 105:354-359(1999).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CXADR protein.
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein, Basolateral cell membrane, Single-pass type I membrane protein, Cell junction, tight junction, Cell junction, adherens junction

Uniprot	P78310
Database Links	HGNC:2559 OMIM:602621 KEGG:hsa:1525 STRING:9606.ENSP00000284878 UniGene:Hs.627078
Function	Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.
Tissue Specificity	Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromusc

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558364	CSB-PA830526	100ul	$297		Add to Cart

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