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Home / Antibodies

CTSD Antibody

SKU : BHA10558901

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA145976
Alternative Names	CATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.Faust P.L., Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).Westley B.R., Nucleic Acids Res. 15:3773-3786(1987).Redecker B., DNA Cell Biol. 10:423-431(1991).
Host	Rabbit
Immunogen	Synthesized peptide derived from Internal of Human CTSD.
Involvement In Disease	Ceroid lipofuscinosis, neuronal, 10 (CLN10)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Faust P.L., Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985). Westley B.R., Nucleic Acids Res. 15:3773-3786(1987). Redecker B., DNA Cell Biol. 10:423-431(1991).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total CTSDprotein.
Subcellular Location	Lysosome, Melanosome, Secreted, extracellular space

Uniprot	P07339
Database Links	HGNC:2529 OMIM:116840 KEGG:hsa:1509 STRING:9606.ENSP00000236671 UniGene:Hs.654447
Function	Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation
Pathway	Estrogen signaling pathway Apoptosis Autophagy
Protein Families	Peptidase A1 family
Tissue Specificity	Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558901	CSB-PA145976	100ul	$297		Add to Cart

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